Tirzepatide is a prescription injection used to help manage:
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Type 2 diabetes
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Weight loss
It mimics two natural gut hormones: GLP-1 and GIP. These help:
Lower blood sugar
Slow digestion (so you feel full longer)
Reduce appetite
How is it taken?
Injection under the skin (subcutaneous)
Once a week, on the same day each week
Can be injected in the stomach, thigh, or upper arm
Beginner Dosages
When starting Mounjaro, doses are increased slowly to reduce side effects like nausea.
| Week | Dose | Notes |
|---|---|---|
| Weeks 1–4 | 2.5 mg | Starting dose – not effective for weight loss, used to get your body used to the medication |
| Weeks 5–8 | 5 mg | First therapeutic dose – many people stay here if goals are met |
| Optional increase (monthly) | 7.5 mg → 10 mg → 12.5 mg → 15 mg | Only if more effect is needed and side effects are tolerable |
Note: Your doctor will guide dose increases – not everyone needs the maximum.
Typical Starting Schedule
| Month | Weekly Dose |
|---|---|
| 1 | 2.5 mg |
| 2 | 5 mg |
| 3 | 7.5 mg or continue 5 mg |
| 4+ | Can increase to 10, 12.5, or 15 mg depending on response and tolerance |
Side Effects (Common)
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Nausea
Diarrhea
Constipation
Decreased appetite
Burping or indigestion
These are usually worse at the start or after a dose increase, and often go away with time.
Warnings / Who Should Avoid It
Not for Type 1 diabetes
Not studied in people with history of medullary thyroid cancer or MEN 2
Talk to your doctor if you have severe stomach issues or pancreatitis
Storage Tips
Store in the fridge
Can be kept at room temp for up to 21 days if needed
Don’t freeze or expose to direct sunlight
Helpful Tips
Take it on the same day each week
If you miss a dose, take it within 4 days, otherwise skip
Eat smaller meals to help with nausea
Drink plenty of water
Summary
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Start at 2.5 mg for 4 weeks
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Gradually increase based on response and side effects
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Once-weekly injection
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Works best with healthy eating and physical activity
